Single‐Subject Network Analysis of FDOPA PET in Parkinson's Disease and Psychosis Spectrum

• Published in: HUMAN BRAIN MAPPING Vol. 46; no. 8; pp. e70253 - n/a
• Main Authors: Severino, Mario, Schubert, Julia J., Nordio, Giovanna, Giacomel, Alessio, Easmin, Rubaida, Lao‐Kaim, Nick P., Selvaggi, Pierluigi, Xu, Zhilei, Pereira, Joana B., Jauhar, Sameer, Piccini, Paola, Howes, Oliver, Turkheimer, Federico, Veronese, Mattia, Angelescu, Ilinca, Bloomfield, Micheal, Bonoldi, Ilaria, Borgan, Faith, Dahoun, Tarik, Enrico, D’Ambrosio, Demjaha, Arsime, Donocik, Jecek, Egerton, Alice, Kaar, Stephen, Kim, Euitae, Kim, Seoyoung, Maccabe, James, Matthews, Julian, McCutcheon, Robert, McGuire, Philip, Nosarti, Chiara, Nour, Matthew M., Rogdaki, Maria, Rutigliano, Grazia, Shatalina, Ekaterina, Talbot, Peter S, Vano, Luke
• Format: Journal Article Publication
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2025
• Subjects: Aged; Antipsychotic drugs; Brain; Brain - diagnostic imaging; Brain - metabolism; Dihydroxyphenylalanine - analogs & derivatives; Diseases; Entacapone; FDOPA; Female; Humans; Male; Middle Aged; molecular connectivity; network analysis; Parkinson Disease - diagnostic imaging; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson's disease; PET; PET imaging; Positron-Emission Tomography - methods; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - drug therapy; Psychotic Disorders - metabolism; Radiopharmaceuticals; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - drug therapy; Schizophrenia - metabolism; Tracers (Biology); FDOPA; network analysis; Parkinson's disease; schizophrenia; molecular connectivity; PET

ABSTRACT Greater understanding of individual biological differences is essential for developing more targeted treatment approaches to complex brain disorders. Traditional analysis methods in molecular imaging studies have primarily focused on quantifying tracer binding in specific brain regions, oft...