Microneedle Array‐Based Platforms for Future Theranostic Applications

• Published in: Chembiochem : a European journal of chemical biology Vol. 20; no. 17; pp. 2198 - 2202
• Main Authors: Howells, Olivia, Rajendran, Natasha, Mcintyre, Sarah, Amini‐Asl, Sara, Henri, Pauline, Liu, Yufei, Guy, Owen, Cass, Anthony E. G., Morris, May C., Sharma, Sanjiv
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.09.2019; Wiley-VCH Verlag
• Subjects: Arrays; artificial pancreas; Biochemistry, Molecular Biology; Biomarkers; Chemical Sciences; Drug delivery; Drug delivery systems; Hypodermic needles; Life Sciences; Medicinal Chemistry; microneedle arrays; Pharmaceutical sciences; Precision medicine; Skin; theranostics; transdermal delivery; Transdermal medication; microneedle arrays; theranostics; artificial pancreas; transdermal delivery; Artificial pancreas; Transdermal delivery; Microneedle arrays; Theranostics
• ISSN: 1439-4227; 1439-7633
• DOI: 10.1002/cbic.201900112

Theranostics involves finding the biomarkers of a disease, fighting them through site specific drug delivery and following them for prognosis of the disease. Microneedle array technology has been used for drug delivery and extended for continuous monitoring of analytes present in the skin compartment. We envisage the use of microneedle arrays for future theranostic applications. The potential of combining microneedle array‐based drug delivery and diagnostics as part of closed‐loop control system for the management of diseases and delivery of precision drugs in individual patients is reported in this paper. The potential of combining microneedle array‐based drug delivery and diagnostics offers a minimally invasive route towards developing wearable closed‐loop control systems. Such systems can be used to manage a plethora of diseases that require continuous/frequent monitoring for subsequent delivery of precision drugs in individual patients.