Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors

A dual‐modal imaging probe based on size‐controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates (see scheme) functionalized with an aptamer (green triangles) that targets 4T1 breast can...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 51; no. 51; pp. 12721 - 12726
Main Authors Tang, Li, Yang, Xujuan, Dobrucki, Lawrence W., Chaudhury, Isthier, Yin, Qian, Yao, Catherine, Lezmi, Stéphane, Helferich, William G., Fan, Timothy M., Cheng, Jianjun
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 14.12.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Animals
aptamers
Aptamers, Nucleotide - chemistry
breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Cell Line, Tumor
Chemistry
Chemistry, Multidisciplinary
dual-modal imaging
Female
Humans
Imaging
Infrared
Lymph
Lymph Nodes - diagnostic imaging
Lymphatic Metastasis
metastasis targeting
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Multimodal Imaging
Nanoconjugates - chemistry
Nanoconjugates - ultrastructure
nanoparticles
Nanostructure
Physical Sciences
Positron-Emission Tomography
Rhodamines - chemistry
Science & Technology
Silicon dioxide
Silicon Dioxide - chemistry
Spectroscopy, Near-Infrared
Tomography
Tomography, X-Ray Computed
Transplantation, Heterologous
Triangles
Tumors
IRON-OXIDE NANOPARTICLES
SYSTEM
TOMOGRAPHY
CELLS
DRUG-DELIVERY
SIZE
metastasis targeting
breast cancer
BIODISTRIBUTION
dual-modal imaging
CANCER METASTASES
nanoparticles
IN-VIVO
aptamers
LIPOSOMES
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Summary:A dual‐modal imaging probe based on size‐controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates (see scheme) functionalized with an aptamer (green triangles) that targets 4T1 breast cancer cells improved the detection efficiency of sentinel lymph nodes with metastatic tumors.
Bibliography:NIH - No. 1DP2OD007246-01; No. 1R21CA152627
ark:/67375/WNG-1LN5WJ18-3
ArticleID:ANIE201205271
J.C. acknowledges support from the NIH (Director's New Innovator Award 1DP2OD007246-01 and 1R21CA152627). L.T. was funded at University of Illinois at Urbana-Champaign from NIH National Cancer Institute Alliance for Nanotechnology in Cancer "Midwest Cancer Nanotechnology Training Center" Grant R25 CA154015A.
istex:DF3132CC14E46B78F5E763B3FE09AFEC22DB0AC5
NIH National Cancer Institute Alliance for Nanotechnology in Cancer - No. R25 CA154015A
J.C. acknowledges support from the NIH (Director’s New Innovator Award 1DP2OD007246‐01 and 1R21CA152627). L.T. was funded at University of Illinois at Urbana‐Champaign from NIH National Cancer Institute Alliance for Nanotechnology in Cancer “Midwest Cancer Nanotechnology Training Center” Grant R25 CA154015A.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201205271