Mucin‐producing urothelial‐type adenocarcinoma of the prostate diagnosed after robot‐assisted radical prostatectomy

• Published in: IJU case reports Vol. 5; no. 1; pp. 32 - 35
• Main Authors: Shimizu, Kosuke, Inoue, Ryo, Tomochika, Shinobu, Isoyama, Naohito, Yamamoto, Yoshiaki, Matsumoto, Hiroaki, Shiraishi, Koji, Yoshino, Shigefumi, Tsuzuki, Toyonori, Matsuyama, Hideyasu
• Format: Journal Article
• Language: English
• Published: Australia John Wiley & Sons, Inc 01.01.2022; John Wiley and Sons Inc; Wiley
• Subjects: Bladder; Cancer therapies; Case Report; Case Reports; Chemotherapy; Colorectal cancer; Conflicts of interest; immunohistochemistry; Magnetic resonance imaging; Medical diagnosis; Metastasis; mucinous adenocarcinoma; Ostomy; Patients; Pelvis; prostate; Prostate cancer; Rare diseases; Surgery; Tomography; urethra; Urological surgery; urothelial‐type; mucinous adenocarcinoma; prostate; immunohistochemistry; urethra; urothelial‐type
• ISSN: 2577-171X; 2577-171X
• DOI: 10.1002/iju5.12380

Introduction Mucin‐producing adenocarcinoma of the prostate is a rare disease that includes prostate adenocarcinoma with mucus production, secondary adenocarcinoma from the bladder or colorectum, and adenocarcinoma from the urothelium of the prostatic urethra. We describe prostate‐specific antigen‐negative mucin‐producing urothelial‐type adenocarcinoma of the prostate. Case presentation The patient had urinary retention and a serum prostate‐specific antigen level of 0.74 ng/mL. Computed tomography and magnetic resonance imaging revealed a prostate tumor with a mucous component. We diagnosed adenocarcinoma by prostate biopsy and subsequently performed robot‐assisted radical prostatectomy. Mucin‐producing urothelial‐type adenocarcinoma of the prostate was diagnosed by pathological examinations. Lung metastasis, developing within 3 months after surgery, was treated using chemotherapy. Conclusion Endocrine therapy is ineffective for mucin‐producing urothelial‐type adenocarcinoma of the prostate. Mucin‐producing urothelial‐type adenocarcinoma of the prostate diagnosis requires pathological and immunohistochemical analyses. It is important to surgically remove the primary lesion, and robot‐assisted radical prostatectomy may provide an effective approach. Multimodal therapy is essential to treat for mucin‐producing urothelial‐type adenocarcinoma of the prostate.