Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

• Published in: Journal of allergy and clinical immunology Vol. 141; no. 1; pp. 429 - 432
• Main Authors: Martinez, Carlos H., Li, Sara X., Hirzel, Andrew J., Stolberg, Valerie R., Alexis, Neil E., Barr, R. Graham, Bleecker, Eugene R., Carretta, Elizabeth E., Christenson, Stephanie A., Cooper, Christopher B., Couper, David J., Doerschuk, Claire M., Han, MeiLan K., Hansel, Nadia N., Hastie, Annette T., Hoffman, Eric A., Kaner, Robert J., Martinez, Fernando J., Meyers, Deborah A., O'Neal, Wanda K., Paine, Robert, Putcha, Nirupama, Rennard, Stephen I., Woodruff, Prescott G., Zeidler, Michelle, Curtis, Jeffrey L., Freeman, Christine M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2018; Elsevier Limited
• Subjects: Allergies; Alveoli; Biomarkers; Biopsy; Chronic obstructive pulmonary disease; Eosinophilia; Eosinophilia - immunology; Eosinophilia - metabolism; Eosinophilia - pathology; Flow cytometry; Humans; Inflammation; Leukocyte Count; Lung diseases; Obstructive lung disease; Pulmonary Alveoli - pathology; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - immunology; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - physiopathology; Respiratory Function Tests; Retention; Smokers; Sputum - cytology; Sputum - immunology
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2017.07.039

[...]we analyzed eosinophil receptor-positivity in the 3 sample types regardless of subject groups (see Fig E2 in this article's Online Repository at www.jacionline.org). [...]we examined the magnitude of receptor expression by mean fluorescence intensity (see Table E2 and Fig E3, A, in this article's Online Repository at www.jacionline.org), which, as with the percent of eosinophils expressing a receptor, differed significantly between sample types for every receptor. In terms of subject comparisons, there were no significant differences in the expression of CD34, CD69, or CD125 by BAL eosinophils, but the expression of CD11b was significantly greater in FS-NAO relative to FS-COPD (Fig E3, B). [...]the expression of CD49d was significantly higher in BAL eosinophils of CS-COPD than in groups other than CS-NAO, which was also elevated relative to FS-COPD (but not to other groups) (Fig E3, B). [...]subjects who agreed to the bronchoscopy substudy were self-selected and may not be representative of the general population.