Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests

Abstract A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger...

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Published inOpen forum infectious diseases Vol. 8; no. 3; p. ofab043
Main Authors Morshed, Muhammad, Sekirov, Inna, McLennan, Meghan, Levett, Paul N, Chahil, Navdeep, Mak, Annie, Carruthers, Erin, Pidduck, Tamara, Kustra, Jesse, Laley, Jonathan, Lee, Min-Kuang, Chu, Kenneth, Burgess, Fred, Vijh, Rohit, Willis, Lori, Wada, Ray, Blancaflor, Rosemarie, Boraston, Suni, Hayden, Althea, Krajden, Mel
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.03.2021
Subjects
Brief Reports
COVID-19
rapid point-of-care test
diagnostic microbiology
public health
serology
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Summary:Abstract A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab043