Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients

• Published in: Vaccine Vol. 22; no. 17; pp. 2199 - 2201
• Main Authors: Vogtländer, N.P.J, Brown, A, Valentijn, R.M, Rimmelzwaan, G.F, Osterhaus, A.D.M.E
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 02.06.2004; Elsevier; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Antibodies, Viral - blood; Applied microbiology; Biological and medical sciences; Booster; Dialysis; Female; Fundamental and applied biological sciences. Psychology; Hemagglutination Inhibition Tests; Hemodialysis; Humans; Immunization; Immunization, Secondary; Influenza; Influenza A virus - immunology; Influenza B virus - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza virus; Influenza, Human - prevention & control; Male; Microbiology; Renal Dialysis; Renal Insufficiency - immunology; Vaccination; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Beijing China; China; Influenza; Vaccine; Booster; Infection; Human; Vaccination coverage; Booster vaccination; Viral disease
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2003.11.046

Dialysis patients show impaired responses to several vaccines. Limited recent data are available on influenza vaccination in these patients. In the 1998–1999 influenza season, 44 dialysis patients received a standard trivalent vaccination followed by a booster two months later. The serum antibody responses in these patients were compaired with those found in healthy subjects. A fourfold rise in serum hemagglutination inhibition titre was achieved in 23–58% of all patients. Protective titres were reached in 53–93% of the patients. Since protective antibody titers can be induced, it is recommended to vaccinate dialysis patients annually against influenza.