Coxiella burnetii Infection Associated With Thromboangiitis Obliterans–like Phenomena With Digital Autoamputation: A Case Report and Review of Q Fever–Associated Autoimmunity

Abstract We present a case of a patient with chronic Q fever who presented with digital necrosis, autoamputations, and positive anticentromere antibody, mimicking a scleroderma vasculopathy or thromboangiitis obliterans. Coxiella burnetii infection has long been associated with the presence of autoa...

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Bibliographic Details
Published inOpen forum infectious diseases Vol. 9; no. 1; p. ofab637
Main Authors Shepard, Zachary, Skorupa, Tara, Espinoza, Leigh, Erlandson, Kristine, Damioli, Laura
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.01.2022
Subjects
Brief Report
autoimmunity
Q fever
anticentromere antibody
thromboangiitis obliterans
Coxiella burnetii
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Summary:Abstract We present a case of a patient with chronic Q fever who presented with digital necrosis, autoamputations, and positive anticentromere antibody, mimicking a scleroderma vasculopathy or thromboangiitis obliterans. Coxiella burnetii infection has long been associated with the presence of autoantibodies and autoimmune phenomena including vasculitis. Clinicians should consider Q fever testing in patients with new-onset autoimmune diseases or autoantibodies and appropriate exposure histories.
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ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab637