Tetanus and diphtheria antibodies and response to a booster dose in Brazilian HIV-1-infected women

• Published in: Vaccine Vol. 22; no. 27; pp. 3707 - 3712
• Main Authors: Bonetti, Tatiana C.S, Succi, Regina C.M, Weckx, Lily Y, Tavares-Lopes, L, de Moraes-Pinto, M.Isabel
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 09.09.2004; Elsevier; Elsevier Limited
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Age; AIDS; Antibodies, Bacterial - analysis; Antibodies, Bacterial - biosynthesis; Applied microbiology; Biological and medical sciences; CD4 Lymphocyte Count; Clostridium tetani; Colleges & universities; Corynebacterium diphtheriae; Dilution; Diphtheria; Diphtheria - immunology; Enzyme-Linked Immunosorbent Assay; Female; Fundamental and applied biological sciences. Psychology; HIV; HIV infection; HIV Infections - immunology; HIV-1; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immunization, Secondary; Microbiology; Older people; Population; Pregnancy; Prenatal care; Regression Analysis; Seroepidemiologic Studies; Tetanus; Tetanus - immunology; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Womens health; Brazil; Diphtheria; HIV infection; Tetanus; Human; Immunopathology; HIV-1 virus; Booster vaccination; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Viral disease; Bacteriosis; Female; Human immunodeficiency virus; Humoral immunity
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2004.03.023

Tetanus and diphtheria (Td) antibodies were studied in HIV-1-infected women during puerperium. HIV group ( n=61) was compared with Control group ( n=101). Twenty-one women from HIV and 13 from Control group who had antibody levels lower than 0.1 IU/mL received a booster with Td vaccine. Antibodies were assessed by double antigen ELISA. Mean tetanus and diphtheria antibody levels from HIV group were lower than those from Control group. Multiple linear regression analysis showed that tetanus and diphtheria antibody levels were decreased by HIV-1-infection, and that was independent of the reduction due to the time interval between last booster and antibody assessment. After a booster dose, both groups had an increase in mean tetanus and diphtheria antibody levels, but in Control group the levels were higher than in HIV group.