A neonate with hand, foot, and mouth disease complicated with brainstem encephalitis and pulmonary edema:A complete recovery

Hand, foot, and mouth disease (HFMD) with serious complications and fatal cases have been reported over the last decade worldwide. The authors report a rare case of HFMD in a neonate complicated with brainstem encephalitis and pulmonary edema. She had fever, lethargy, dyspnea. Physical examination r...

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Bibliographic Details
Published inPakistan journal of medical sciences Vol. 30; no. 4; pp. 917 - 919
Main Authors Guo, Shi-Jie, Wang, Dong-Xuan, Dai, Chun-Lai, Wu, Hui
Format Journal Article
LanguageEnglish
Published Pakistan Knowledge Bylanes 31.08.2014
AsiaNet Pakistan (Pvt) Ltd
Professional Medical Publicaitons
Subjects
Case Report
Coxsackievirus infections
Encephalitis
Infants (Newborn)
Pulmonary edema
Enterovirus 71
Foot and mouth disease
Neonate
Brainstem encephalitis
Hand
Pulmonary edema
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Summary:Hand, foot, and mouth disease (HFMD) with serious complications and fatal cases have been reported over the last decade worldwide. The authors report a rare case of HFMD in a neonate complicated with brainstem encephalitis and pulmonary edema. She had fever, lethargy, dyspnea. Physical examination revealed shock signs, fine rales on both lungs, absent Moro reflex. The patient had a rapidly progressive course with seizures, coma, no spontaneous breathing, chemosis. There were some vesicles on left sole and red maculopapular rashes on perianal skin. She had a history of exposure to HFMD. Fecal sample was positive for EV71 RNA by real-time PCR. Chest X-rays showed bilateral pulmonary infiltrates. MRI of the brain showed significant hypointensity in the brainstem on T1WI and hyperintensity on T2WI. She recovered well. This case highlights severe HFMD in neonates is rare. Medical history and physical examination are important in making diagnosis.
ISSN:1682-024X
1681-715X
DOI:10.12669/pjms.304.4528