Hepatitis C Virus Exploitation of Processing Bodies

During infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to translate viral proteins and replicate viral genomes to avoid or disable the host defense mechanisms. Cytoplasmic RNA granules modulate the stabilities of cellular and viral RNAs. Understanding how...

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Bibliographic Details
Published inJournal of virology Vol. 90; no. 10; pp. 4860 - 4863
Main Authors Biegel, Jason M, Pager, Cara T
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 15.05.2016
Subjects
Cytoplasmic Granules - genetics
Cytoplasmic Granules - immunology
Cytoplasmic Granules - metabolism
Cytoplasmic Granules - ultrastructure
Gems
Genome, Viral
Hepacivirus - genetics
Hepacivirus - immunology
Hepacivirus - physiology
Hepatitis C virus
Host-Pathogen Interactions
Humans
MicroRNAs - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Small Interfering - immunology
RNA, Viral - genetics
RNA, Viral - metabolism
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Summary:During infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to translate viral proteins and replicate viral genomes to avoid or disable the host defense mechanisms. Cytoplasmic RNA granules modulate the stabilities of cellular and viral RNAs. Understanding how hepatitis C virus and other flaviviruses interact with the host machinery required for protein synthesis, localization, and degradation of mRNAs is important for elucidating how these processes occur in both virus-infected and uninfected cells.
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Citation Biegel JM, Pager CT. 2016. Hepatitis C virus exploitation of processing bodies. J Virol 90:4860–4863. doi:10.1128/JVI.03056-15.
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.03056-15