Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

• Published in: Revista Brasileira de Enfermagem Vol. 71; no. 4; pp. 1921 - 1927
• Main Authors: Vasco, Carolina Ferreira, Watanabe, Mirian, Fonseca, Cassiane Dezoti da, Vattimo, Maria de Fátima Fernandes
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Associação Brasileira de Enfermagem 01.07.2018
• Subjects: Abdomen; Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Acute Kidney Injury - drug therapy; Acute Kidney Injury - prevention & control; Animals; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Blood pressure; Brazil; Cecum - drug effects; Cecum - injuries; Diosmin - pharmacology; Diosmin - therapeutic use; Diosmina; Disease Models, Animal; DNA damage; Estrés Oxidativo; Heart attacks; Hesperidin - pharmacology; Hesperidin - therapeutic use; Hesperidina; Kidneys; Lesión Renal Aguda; Mortality; Nursing; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Rats; Rodents; Sepsis; Sepsis - complications; Sepsis - drug therapy; Brazil
• ISSN: 0034-7167; 1984-0446; 1984-0446
• DOI: 10.1590/0034-7167-2017-0469

To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.