Leukemic transformation of Langerhans cell sarcoma

A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despi...

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Bibliographic Details
Published inInternational journal of hematology Vol. 87; no. 5; pp. 527 - 531
Main Authors Sumida, Kousuke, Yoshidomi, Yuya, Koga, Hiroko, Kuwahara, Nobuo, Matsuishi, Eijo, Karube, Kennosuke, Oshima, Koichi, Gondo, Hisashi
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.06.2008
Springer
Springer Nature B.V
Subjects
Antigens, CD - immunology
Biological and medical sciences
Case Report
Diagnosis, Differential
Fatal Outcome
Hematologic and hematopoietic diseases
Hematology
Humans
Immunophenotyping - methods
Langerhans Cell Sarcoma - immunology
Langerhans Cell Sarcoma - pathology
Leukemia, Myeloid, Acute - immunology
Leukemia, Myeloid, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Langerhans cell sarcoma
Leukemic transformation
Acute myelogenous leukemia
Langerhans cell
Hematology
Sarcoma
Antigen presenting cell
Malignant hemopathy
Malignant tumor
Cell transformation
Carcinogenesis
Langerhans cell sarcoma, Leukemic transformation
Cancer
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Summary:A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of disease progression 7 months after the initial diagnosis. Tumor cells in the leukemic phase expressed CD5, CD7, CD13, CD33, CD34, CD68, and CD123. These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia.
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ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-008-0063-x