Studies on mechanism of action of glycyrrhizin against hepatitis A virus replication in vitro

Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [3H]uridine-labelled virions to...

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Bibliographic Details
Published inAntiviral research Vol. 23; no. 1; p. 63
Main Authors Crance, J M, Lévêque, F, Biziagos, E, van Cuyck-Gandré, H, Jouan, A, Deloince, R
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.1994
Subjects
Antigens, Viral - drug effects
Antigens, Viral - metabolism
Antiviral Agents - pharmacology
Carcinoma, Hepatocellular
Glycyrrhetinic Acid - analogs & derivatives
Glycyrrhetinic Acid - pharmacology
Glycyrrhizic Acid
Hepatitis A Antigens
Hepatovirus - drug effects
Hepatovirus - immunology
Hepatovirus - pathogenicity
Hepatovirus - physiology
Time Factors
Tumor Cells, Cultured
Virus Replication - drug effects
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Summary:Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [3H]uridine-labelled virions to cells. GL inhibited HAV penetration of the plasma membrane as measured by the amount of infective virus no longer neutralizable by specific antibody over time.
ISSN:0166-3542
DOI:10.1016/0166-3542(94)90033-7