Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats

• Published in: Metabolism, clinical and experimental Vol. 63; no. 4; pp. 452 - 455
• Main Authors: Disanzo, Beth L, You, Tongjian
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2014; Elsevier
• Subjects: Adipose Tissue - blood supply; Animals; Biological and medical sciences; Biomarkers - metabolism; Endocrinology & Metabolism; Fat tissue; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Hypoxia - physiopathology; Lactate; Lactic Acid - metabolism; Male; Medical sciences; Metabolic diseases; Neovascularization, Pathologic; Obesity; Obesity - physiopathology; Physical Conditioning, Animal; Rats; Rats, Zucker; Treadmill walking; Vascular Endothelial Growth Factor A - metabolism; VEGF-A; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Obesity; Treadmill walking; Lactate; PGC-1α; VEGF-A; vascular endothelial growth factor A; peroxisome proliferator-activated receptor gamma coactivator 1 alpha; Fat tissue; Physical exercise; Oxygen; Adipose tissue; Rat; Rodentia; Nutrition disorder; Indicator; Angiogenesis; Vertebrata; Mammalia; Animal; Hypoxia; Endocrinology; Nutritional status
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2013.12.004

Abstract Objective To investigate the effects of obesity and exercise training on regional adipose tissue angiogenesis and hypoxia markers in rats. Methods Lean (Fa/Fa) and obese (fa/fa) male Zucker rats at 2 months of age were randomly assigned to a sedentary or an exercise training group (lean sedentary: n = 7, lean exercise: n = 8, obese sedentary: n = 7, obese exercise: n = 8). The exercise group walked on a rat treadmill 5 times per week for 8 weeks. Inguinal and epididymal adipose tissue vascular endothelial growth factor A (VEGF-A) and lactate levels were determined. Results There were significant effects of obesity in increasing inguinal (P < 0.001) and epididymal (P < 0.05) adipose tissue VEGF-A, and a significant effect of exercise training in increasing epididymal adipose tissue VEGF-A (P < 0.05). There was a significant effect of obesity in increasing inguinal adipose tissue lactate levels (P < 0.001). Compared to lean sedentary animals, obese sedentary animals had significantly higher epididymal adipose tissue lactate levels (P < 0.001); compared to obese sedentary animals, obese exercise rats had significantly lower epididymal adipose tissue lactate levels (P < 0.05). Conclusions Exercise training increased adipose tissue VEGF-A, an important factor of tissue angiogenesis, and lowered adipose tissue lactate, an indicator of adipose tissue hypoxia in obese rats. However, these effects are depot-specific and only observed in intra-abdominal adipose tissue.