Minimum heart rate and coronary atherosclerosis: Independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age
The relations of hemodynamic factors, plasma fibrinogen concentration, serum lipoprotein levels, and clinical risk indicators to coronary atherosclerosis were studied in 56 men who had survived a first myocardial infarction before the age of 45 years and who subsequently underwent two coronary angio...
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Published in | The American heart journal Vol. 123; no. 3; pp. 609 - 616 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Mosby, Inc
01.03.1992
Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | The relations of hemodynamic factors, plasma fibrinogen concentration, serum lipoprotein levels, and clinical risk indicators to coronary atherosclerosis were studied in 56 men who had survived a first myocardial infarction before the age of 45 years and who subsequently underwent two coronary angiographies with an intervening time interval of 4 to 7 years. Presence, severity, and rate of progression of both diffuse lesions and distinct stenoses were determined by means of separate classification systems in 15 proximal coronary arterial segments. High minimum heart rate measured during a 24-hour period in connection with the reangiography was associated with progression of both diffuse lesions and distinct stenoses. High minimum heart rate also correlated positively with angiographic scores of global severity of diffuse atherosclerosis and stenoses. Progression of disease was predicted independently by minimum heart rate and low-density lipoprotein/high-density lipoprotein ratio, whereas lipoprotein A, fibrinogen levels, hypertension, smoking, and β-adrenergic receptor blockade treatment did not discriminate between patients with and without progression. |
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AbstractList | The relations of hemodynamic factors, plasma fibrinogen concentration, serum lipoprotein levels, and clinical risk indicators to coronary atherosclerosis were studied in 56 men who had survived a first myocardial infarction before the age of 45 years and who subsequently underwent two coronary angiographies with an intervening time interval of 4 to 7 years. Presence, severity, and rate of progression of both diffuse lesions and distinct stenoses were determined by means of separate classification systems in 15 proximal coronary arterial segments. High minimum heart rate measured during a 24-hour period in connection with the reangiography was associated with progression of both diffuse lesions and distinct stenoses. High minimum heart rate also correlated positively with angiographic scores of global severity of diffuse atherosclerosis and stenoses. Progression of disease was predicted independently by minimum heart rate and low-density lipoprotein/high-density lipoprotein ratio, whereas lipoprotein A, fibrinogen levels, hypertension, smoking, and β-adrenergic receptor blockade treatment did not discriminate between patients with and without progression. The relations of hemodynamic factors, plasma fibrinogen concentration, serum lipoprotein levels, and clinical risk indicators to coronary atherosclerosis were studied in 56 men who had survived a first myocardial infarction before the age of 45 years and who subsequently underwent two coronary angiographies with an intervening time interval of 4 to 7 years. Presence, severity, and rate of progression of both diffuse lesions and distinct stenoses were determined by means of separate classification systems in 15 proximal coronary arterial segments. High minimum heart rate measured during a 24-hour period in connection with the reangiography was associated with progression of both diffuse lesions and distinct stenoses. High minimum heart rate also correlated positively with angiographic scores of global severity of diffuse atherosclerosis and stenoses. Progression of disease was predicted independently by minimum heart rate and low-density lipoprotein/high-density lipoprotein ratio, whereas lipoprotein A, fibrinogen levels, hypertension, smoking, and beta-adrenergic receptor blockade treatment did not discriminate between patients with and without progression. |
Author | Landou, Christian Hamsten, Anders Perski, Aleksander de Faire, Ulf Olsson, Gunnar Theorell, Töres |
Author_xml | – sequence: 1 givenname: Aleksander surname: Perski fullname: Perski, Aleksander organization: National Institute for Psychosocial Factors and Health, Stockholm, Sweden – sequence: 2 givenname: Gunnar surname: Olsson fullname: Olsson, Gunnar organization: National Institute for Psychosocial Factors and Health, Stockholm, Sweden – sequence: 3 givenname: Christian surname: Landou fullname: Landou, Christian organization: National Institute for Psychosocial Factors and Health, Stockholm, Sweden – sequence: 4 givenname: Ulf surname: de Faire fullname: de Faire, Ulf organization: National Institute for Psychosocial Factors and Health, Stockholm, Sweden – sequence: 5 givenname: Töres surname: Theorell fullname: Theorell, Töres organization: National Institute for Psychosocial Factors and Health, Stockholm, Sweden – sequence: 6 givenname: Anders surname: Hamsten fullname: Hamsten, Anders organization: National Institute for Psychosocial Factors and Health, Stockholm, Sweden |
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Keywords | Heart Human Flow rate Angiography Infarct Radiodiagnosis Cardiovascular disease Exploration Lipoprotein Coronary heart disease Young adult Atherosclerosis Myocardium Evolution Serum Hemodynamics |
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SubjectTerms | Adult Age Factors Biological and medical sciences Cardiology. Vascular system Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Angiography Coronary Artery Disease - diagnosis Coronary Artery Disease - epidemiology Coronary heart disease Electrocardiography, Ambulatory Fibrinogen - analysis Follow-Up Studies Heart Heart Rate - physiology Humans Male Medical sciences Myocardial Infarction - epidemiology Regression Analysis Risk Factors |
Title | Minimum heart rate and coronary atherosclerosis: Independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age |
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