Minimum heart rate and coronary atherosclerosis: Independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age

• Published in: The American heart journal Vol. 123; no. 3; pp. 609 - 616
• Main Authors: Perski, Aleksander, Olsson, Gunnar, Landou, Christian, de Faire, Ulf, Theorell, Töres, Hamsten, Anders
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.03.1992; Elsevier
• Subjects: Adult; Age Factors; Biological and medical sciences; Cardiology. Vascular system; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Coronary Angiography; Coronary Artery Disease - diagnosis; Coronary Artery Disease - epidemiology; Coronary heart disease; Electrocardiography, Ambulatory; Fibrinogen - analysis; Follow-Up Studies; Heart; Heart Rate - physiology; Humans; Male; Medical sciences; Myocardial Infarction - epidemiology; Regression Analysis; Risk Factors; Heart; Human; Flow rate; Angiography; Infarct; Radiodiagnosis; Cardiovascular disease; Exploration; Lipoprotein; Coronary heart disease; Young adult; Atherosclerosis; Myocardium; Evolution; Serum; Hemodynamics
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/0002-8703(92)90497-J

The relations of hemodynamic factors, plasma fibrinogen concentration, serum lipoprotein levels, and clinical risk indicators to coronary atherosclerosis were studied in 56 men who had survived a first myocardial infarction before the age of 45 years and who subsequently underwent two coronary angiographies with an intervening time interval of 4 to 7 years. Presence, severity, and rate of progression of both diffuse lesions and distinct stenoses were determined by means of separate classification systems in 15 proximal coronary arterial segments. High minimum heart rate measured during a 24-hour period in connection with the reangiography was associated with progression of both diffuse lesions and distinct stenoses. High minimum heart rate also correlated positively with angiographic scores of global severity of diffuse atherosclerosis and stenoses. Progression of disease was predicted independently by minimum heart rate and low-density lipoprotein/high-density lipoprotein ratio, whereas lipoprotein A, fibrinogen levels, hypertension, smoking, and β-adrenergic receptor blockade treatment did not discriminate between patients with and without progression.