Prevention of binding of rgp120 by anti-HIV active tannins

Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587-595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgp120 to CD4. These compounds were not toxic to stimulated human peripheral blood l...

Full description

Saved in:
Bibliographic Details
Published inBiochemical pharmacology Vol. 43; no. 11; p. 2479
Main Authors Weaver, J L, Pine, P S, Dutschman, G, Cheng, Y C, Lee, K H, Aszalos, A
Format Journal Article
LanguageEnglish
Published England 09.06.1992
Subjects
Antiviral Agents - pharmacology
CD4 Antigens - metabolism
Drug Design
HIV Envelope Protein gp120 - metabolism
Humans
Lymphocytes - drug effects
Lymphocytes - immunology
Protein Binding - drug effects
Recombinant Proteins - metabolism
Tannins - pharmacology
Online AccessGet more information

Cover

More Information
Summary:Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587-595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgp120 to CD4. These compounds were not toxic to stimulated human peripheral blood lymphocytes at concentrations ten times above their maximal effective concentration.
ISSN:0006-2952
DOI:10.1016/0006-2952(92)90328-g