Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells

Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8)...

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Published inMarine drugs Vol. 21; no. 10; p. 529
Main Authors Cheng, Ming-Ya, Chuang, Ya-Ting, Chang, Hsueh-Wei, Lin, Zheng-Yu, Chen, Ching-Yeu, Cheng, Yuan-Bin
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 08.10.2023
MDPI
Subjects
Absolute configuration
Cancer
Cancer therapies
Carbon
cell lines
Chemotherapy
Circular dichroism
circular dichroism spectroscopy
Clavularia
Clavularia spp
Corals
Cytotoxicity
Data analysis
Dichroism
diterpenoids
dolabellane
eudensamane-type sesquiterpene lactone
Lactones
Marine invertebrates
mouth neoplasms
Natural products
neoplasm cells
NMR
Nuclear magnetic resonance
Oral cancer
Sesquiterpene lactones
sesquiterpenoid lactones
spectral analysis
Taiwan
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Summary:Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC50 value of 7.26 ± 0.17 μg/mL.
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These authors contributed equally to this work.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21100529