Effects of short-term administration of tolvaptan after open heart surgery

• Published in: International journal of cardiology Vol. 220; pp. 192 - 195
• Main Authors: Matsuyama, Katsuhiko, Koizumi, Nobusato, Nishibe, Toshiya, Iwasaki, Tomoaki, Iwahasi, Toru, Toguchi, Kayo, Takahashi, Satoshi, Iwahori, Akinari, Maruno, Keita, Ogino, Hitoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.10.2016
• Subjects: Aged; Antidiuretic Hormone Receptor Antagonists - administration & dosage; Antidiuretic Hormone Receptor Antagonists - adverse effects; Benzazepines - administration & dosage; Benzazepines - adverse effects; Body Weight - drug effects; Body Weight - physiology; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - methods; Cardiovascular; Diuretics; Diuretics - administration & dosage; Diuretics - adverse effects; Drug Monitoring; Drug Therapy, Combination - methods; Female; Fluid Shifts - drug effects; Furosemide - administration & dosage; Furosemide - adverse effects; Heart failure; Humans; Male; Middle Aged; Postoperative Complications - diagnosis; Postoperative Complications - drug therapy; Postoperative Complications - etiology; Postoperative Complications - physiopathology; Spironolactone - administration & dosage; Spironolactone - adverse effects; Surgery; Tolvaptan; Treatment Outcome; Urinalysis - methods; tolvaptan; Diuretics; heart failure; surgery; Heart failure; Tolvaptan; Surgery

Abstract Background Postoperative fluid overload following cardiac surgery is associated with increased morbidity and mortality. Unlike loop diuretics, tolvaptan (TLV) promotes aquaretic effect. Relatively little has been documented regarding the efficacy of TLV after cardiac surgery. The aim of the...