Effects of short-term administration of tolvaptan after open heart surgery

• Published in: International journal of cardiology Vol. 220; pp. 192 - 195
• Main Authors: Matsuyama, Katsuhiko, Koizumi, Nobusato, Nishibe, Toshiya, Iwasaki, Tomoaki, Iwahasi, Toru, Toguchi, Kayo, Takahashi, Satoshi, Iwahori, Akinari, Maruno, Keita, Ogino, Hitoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.10.2016
• Subjects: Aged; Antidiuretic Hormone Receptor Antagonists - administration & dosage; Antidiuretic Hormone Receptor Antagonists - adverse effects; Benzazepines - administration & dosage; Benzazepines - adverse effects; Body Weight - drug effects; Body Weight - physiology; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - methods; Cardiovascular; Diuretics; Diuretics - administration & dosage; Diuretics - adverse effects; Drug Monitoring; Drug Therapy, Combination - methods; Female; Fluid Shifts - drug effects; Furosemide - administration & dosage; Furosemide - adverse effects; Heart failure; Humans; Male; Middle Aged; Postoperative Complications - diagnosis; Postoperative Complications - drug therapy; Postoperative Complications - etiology; Postoperative Complications - physiopathology; Spironolactone - administration & dosage; Spironolactone - adverse effects; Surgery; Tolvaptan; Treatment Outcome; Urinalysis - methods; tolvaptan; Diuretics; heart failure; surgery; Heart failure; Tolvaptan; Surgery
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2016.06.156

Abstract Background Postoperative fluid overload following cardiac surgery is associated with increased morbidity and mortality. Unlike loop diuretics, tolvaptan (TLV) promotes aquaretic effect. Relatively little has been documented regarding the efficacy of TLV after cardiac surgery. The aim of the study was to investigate the effectiveness and safety of tolvaptan for the management of immediately postoperative fluid retention following cardiac surgery. Methods Between January to May 2014, patients undergoing cardiac surgery were randomly assigned to control or TLV group immediately after cardiac surgery. In control group, patients received 20 mg of furosemide and 25 mg of spironolactone as conventional diuretics. In the TLV group, 7.5 mg of TLV was administered in combination with conventional diuretics. Results TLV use was associated with increased urine output from postoperative day 1 to 3.Body weight reduction in the TLV group was significantly greater than the control group from postoperative day 2 to 4, and serum creatinine levels decreased to below preoperative values in the TLV group. Conclusions The combination of tolvaptan with conventional diuretics increases urine output without renal dysfunction and can be effective for postoperative fluid management and appropriate body weight reduction.