Three-Dimensional-Printed Composite Scaffolds Containing Poly-ε-Caprolactone and Strontium-Doped Hydroxyapatite for Osteoporotic Bone Restoration

A challenge in tissue engineering and the pharmaceutical sector is the development of controlled local release of drugs that raise issues when systemic administration is applied. Strontium is an example of an effective anti-osteoporotic agent, used in treating osteoporosis due to both anti-resorptiv...

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Published inPolymers Vol. 16; no. 11; p. 1511
Main Authors Codrea, Cosmin Iulian, Lincu, Daniel, Ene, Vladimir Lucian, Nicoară, Adrian Ionuț, Stan, Miruna Silvia, Ficai, Denisa, Ficai, Anton
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2024
MDPI
Subjects
3-D printers
Biocompatibility
Biological activity
Biomedical materials
Bones
Care and treatment
Chemical properties
Composite materials
Design
Hydroxyapatite
Mechanical properties
Multilayers
Osteoporosis
Polycaprolactone
Polymers
Recovery (Medical)
Regeneration (physiology)
Scaffolds
Strontium
Three dimensional composites
Tissue engineering
Romania
bioactivity
strontium
co-precipitation
hydrothermal
poly-ε-caprolactone
3D printing
hydroxyapatite nano-powder
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Summary:A challenge in tissue engineering and the pharmaceutical sector is the development of controlled local release of drugs that raise issues when systemic administration is applied. Strontium is an example of an effective anti-osteoporotic agent, used in treating osteoporosis due to both anti-resorptive and anabolic mechanisms of action. Designing bone scaffolds with a higher capability of promoting bone regeneration is a topical research subject. In this study, we developed composite multi-layer three-dimensional (3D) scaffolds for bone tissue engineering based on nano-hydroxyapatite (HA), Sr-containing nano-hydroxyapatite (SrHA), and poly-ε-caprolactone (PCL) through the material extrusion fabrication technique. Previously obtained HA and SrHA with various Sr content were used for the composite material. The chemical, morphological, and biocompatibility properties of the 3D-printed scaffolds obtained using HA/SrHA and PCL were investigated. The 3D composite scaffolds showed good cytocompatibility and osteogenic potential, which is specifically recommended in applications when faster mineralization is needed, such as osteoporosis treatment.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym16111511