Tec Family Kinases in Inflammation and Disease

Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell developme...

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Published inInternational Reviews of Immunology Vol. 32; no. 2; pp. 87 - 103
Main Authors Horwood, Nicole J., Urbaniak, Ania M., Danks, Lynett
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.04.2012
Taylor & Francis
Subjects
Animals
arthritis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - metabolism
Autoimmune Diseases - drug therapy
Autoimmune Diseases - metabolism
btk
Enzyme Inhibitors - therapeutic use
Humans
inflammation
Inflammation - metabolism
Mice
Myeloid Cells - cytology
Myeloid Cells - metabolism
Protein-Tyrosine Kinases - antagonists & inhibitors
Protein-Tyrosine Kinases - classification
Protein-Tyrosine Kinases - metabolism
tyrosine kinase
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Summary:Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0883-0185
1937-4364
1563-5244
DOI:10.3109/08830185.2012.670334