Vaccination and ill-health in dogs: a lack of temporal association and evidence of equivalence

Following concerns raised over the safety of canine vaccines, an epidemiological investigation was conducted to evaluate the evidence for a temporal association between vaccination and ill-health in dogs. The owners of a randomly selected population of dogs were sent 9055 postal questionnaires, 4040...

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Bibliographic Details
Published inVaccine Vol. 22; no. 25; pp. 3270 - 3273
Main Authors Edwards, D.S, Henley, W.E, Ely, E.R, Wood, J.L.N
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 03.09.2004
Elsevier
Elsevier Limited
Subjects
Age
Animals
Applied microbiology
Biological and medical sciences
Biomedical research
Canine
Confidence intervals
Cross-Sectional Studies
Demography
Dog Diseases - epidemiology
Dogs
Equivalence-test
Female
Fundamental and applied biological sciences. Psychology
Health Status Indicators
Hypotheses
Illnesses
Logistics
Male
Microbiology
Questionnaires
Safety
Statistical methods
Studies
Surveys and Questionnaires
Temporal-association
Time Factors
Tropical diseases
United Kingdom - epidemiology
Vaccination
Vaccination - adverse effects
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Variables
Safety
Equivalence-test
Vaccination
Temporal-association
Canine
Fissipedia
Carnivora
Vertebrata
Mammalia
Toxicity
Veterinary
Dog
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Summary:Following concerns raised over the safety of canine vaccines, an epidemiological investigation was conducted to evaluate the evidence for a temporal association between vaccination and ill-health in dogs. The owners of a randomly selected population of dogs were sent 9055 postal questionnaires, 4040 of which were returned. No temporal association was found between vaccination and ill-health in dogs after adjusting for potential confounders, such as age. However, reliable inferences from non-significant test results are limited and so equivalence-testing methods were also used to make informative inferences. Results demonstrated that recent vaccination (<3 months) does not increase signs of ill-health by more than 0.5% and may actually decrease it by as much as 5%. This general approach should be used in all field studies of vaccine safety.
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ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.03.038