Prevalence and antimicrobial susceptibility of non-fermenting Gram-negative bacilli isolated from clinical samples at a tertiary care hospital

• Published in: Revista da Sociedade Brasileira de Medicina Tropical Vol. 50; no. 2; pp. 243 - 247
• Main Authors: Argenta, Anne de Rossi, Fuentefria, Daiane Bopp, Sobottka, Andréa Michel
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Medicina Tropical 01.03.2017; Sociedade Brasileira de Medicina Tropical - SBMT; Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Adolescent; Adult; Age; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial agents; Bacilli; Bacterial resistance; beta-Lactamases - biosynthesis; Biological effects; Biological materials; Child; Child, Preschool; Female; Gram-negative bacilli; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - enzymology; Gram-Negative Bacteria - isolation & purification; Gram-Negative Bacterial Infections - microbiology; Humans; Infant; Infant, Newborn; Male; Metallo-beta-lactamase; Metallo-β-lactamase; Metallography; Microbial Sensitivity Tests; Middle Aged; Nosocomial infections; Penicillin; Prevalence; Reduction (metal working); Sex; Tertiary Care Centers; TROPICAL MEDICINE; Young Adult; Metallo-beta-lactamase; Bacterial resistance; Nosocomial infections
• ISSN: 0037-8682; 1678-9849; 1678-9849; 0037-8682
• DOI: 10.1590/0037-8682-0371-2016

We compared the prevalence and antimicrobial susceptibility of non-fermenting gram-negative bacilli (NFGNB) isolated from clinical samples at a Brazilian tertiary care hospital in 2008 and 2013. Collected data included patient's name, age, sex, inpatient unit, laboratory record number, type of biological material, culture test result, and antimicrobial susceptibility of isolated strains. Out of 19,112 culture tests analyzed, 926 (4.8%) were positive for NFGNB. Among these, 45.2% were metallo-beta-lactamase (MBL) producing strains. Between 2008 and 2013, the number of MBL-producing NFGNB isolates increased by 21.5%, which was accompanied by a consequent reduction in susceptibility to antimicrobials.