Cellular transcriptome analysis reveals differential expression of pro- and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts

Transcriptional changes following varicella-zoster virus (VZV) infection of cultured human neurons derived from embryonic stem cells were compared to those in VZV-infected human foreskin fibroblasts. Transcription of 340 neuronal genes significantly altered by VZV infection included 223 transcript c...

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Published inJournal of virology Vol. 88; no. 13; pp. 7674 - 7677
Main Authors Markus, Amos, Waldman Ben-Asher, Hiba, Kinchington, Paul R, Goldstein, Ronald S
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.07.2014
Subjects
Apoptosis - genetics
Biomarkers - metabolism
Cells, Cultured
Cellular Response to Infection
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Embryonic Stem Cells - virology
Fibroblasts - cytology
Fibroblasts - metabolism
Fibroblasts - virology
Gene Expression Profiling
Herpesvirus 3, Human - physiology
Humans
Neurons - cytology
Neurons - metabolism
Neurons - virology
Oligonucleotide Array Sequence Analysis
Varicella-zoster virus
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Summary:Transcriptional changes following varicella-zoster virus (VZV) infection of cultured human neurons derived from embryonic stem cells were compared to those in VZV-infected human foreskin fibroblasts. Transcription of 340 neuronal genes significantly altered by VZV infection included 223 transcript changes unique to neurons. Strikingly, genes inhibiting apoptosis were upregulated in neurons, while proapoptotic gene transcription was increased in fibroblasts. These data are a basis for discovery of differences in virus-host interactions between these VZV targets.
Bibliography:ObjectType-Article-1
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ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.00500-14