Campylobacter jejuni Infection and Guillain–Barré Syndrome

Guillain–Barré syndrome is the most common cause of acute neuromuscular paralysis, 1 yet its cause and pathogenesis are unknown. In approximately two thirds of patients, neuropathic symptoms follow an infection — often a mild, undiagnosed respiratory or gastrointestinal illness. The organism that ha...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 333; no. 21; pp. 1374 - 1379
Main Authors Rees, Jeremy H, Soudain, Sara E, Gregson, Norman A, Hughes, Richard A.C
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 23.11.1995
Subjects
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Campylobacter Infections - complications
Campylobacter Infections - microbiology
Campylobacter jejuni - isolation & purification
Case-Control Studies
Diarrhea - complications
Diarrhea - microbiology
Female
Human bacterial diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Middle Aged
Multivariate Analysis
Patients
Polyneuropathies - microbiology
Polyradiculoneuropathy - classification
Polyradiculoneuropathy - microbiology
Polyradiculoneuropathy - mortality
Prognosis
Prospective Studies
Severity of Illness Index
Sex Factors
Syndrome
Teaching hospitals
Human
Infection
Nervous system diseases
Association
Prognosis
Campylobacteraceae
Bacteria
Peripheral nerve disease
Epidemiology
Guillain Barré syndrome
Inflammatory disease
Campylobacter jejuni
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Summary:Guillain–Barré syndrome is the most common cause of acute neuromuscular paralysis, 1 yet its cause and pathogenesis are unknown. In approximately two thirds of patients, neuropathic symptoms follow an infection — often a mild, undiagnosed respiratory or gastrointestinal illness. The organism that has most frequently been described in association with Guillain–Barré syndrome is Campylobacter jejuni, a gram-negative rod that is now the most common cause of bacterial gastroenteritis in developed countries. Although there has been a plethora of case reports and studies documenting the association, 2 the specific clinical and epidemiologic features are not well known. In addition, there is controversy about . . .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199511233332102