Effect of local radiotherapy for bone pain on urinary markers of osteoclast activity

• Published in: The Lancet (British edition) Vol. 355; no. 9213; pp. 1428 - 1429
• Main Authors: Hoskin, PJ, Stratford, MRL, Folkes, LK, Regan, J, Yarnold, JR
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 22.04.2000; Lancet; Elsevier Limited
• Subjects: Amino Acids - urine; Biological and medical sciences; Biomarkers - urine; Bone Neoplasms - complications; Bone Neoplasms - secondary; Bone Resorption - etiology; Bone Resorption - urine; Bones; Breast Neoplasms - pathology; Clinical trials; Diseases of the osteoarticular system. Orthopedic treatment; Female; Humans; Male; Medical sciences; Pain; Pain - diagnosis; Pain - etiology; Pain - radiotherapy; Pain Measurement; Prospective Studies; Prostatic Neoplasms - pathology; Radiation; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Therapy; Treatment Outcome; Human; Urine; Diseases of the osteoarticular system; Biological marker; Resorption; Activity; Osteoclast; Malignant tumor; Metastasis; Radiotherapy; Biological activity; Pain; Treatment; Bone
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(00)02144-9

Urinary markers of bone resorption, pyridinoline and deoxypyridinoline were measured before and at 4 weeks after radiotherapy for metastatic bone pain. An association was shown between relief of metastatic skeletal pain by radiotherapy and low marker concentrations before and after treatment, lending support to the hypothesis that relief of metastatic bone pain by radiotherapy relates to an effect on bone, rather than tumour physiology.