Laboratory Diagnosis of Congenital Toxoplasmosis

Recent studies have demonstrated that screening and treatment for toxoplasmosis during gestation result in a decrease of vertical transmission and clinical sequelae. Early treatment was associated with improved outcomes. Thus, laboratory methods should aim for early identification of infants with co...

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Bibliographic Details
Published inJournal of clinical microbiology Vol. 54; no. 10; pp. 2448 - 2454
Main Authors Pomares, Christelle, Montoya, Jose G
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.10.2016
Subjects
Clinical Laboratory Techniques - methods
Diagnostic Tests, Routine - methods
Humans
Minireviews
Serologic Tests - methods
Toxoplasma
Toxoplasmosis, Congenital - diagnosis
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Summary:Recent studies have demonstrated that screening and treatment for toxoplasmosis during gestation result in a decrease of vertical transmission and clinical sequelae. Early treatment was associated with improved outcomes. Thus, laboratory methods should aim for early identification of infants with congenital toxoplasmosis (CT). Diagnostic approaches should include, at least, detection of Toxoplasma IgG, IgM, and IgA and a comprehensive review of maternal history, including the gestational age at which the mother was infected and treatment. Here, we review laboratory methods for the diagnosis of CT, with emphasis on serological tools. A diagnostic algorithm that takes into account maternal history is presented.
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Citation Pomares C, Montoya JG. 2016. Laboratory diagnosis of congenital toxoplasmosis. J Clin Microbiol 54:2448–2454. doi:10.1128/JCM.00487-16.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.00487-16