Chrysotherapy in the treatment of corticosteroid-dependent asthma

The efficacy of parenteral gold therapy was evaluated in patients with steroid-dependent asthma. Five of eight patients improved in terms of reduced steroid requirement while they were maintaining or improving lung function. Two patients developed significant proteinuria that resolved with cessation...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 79; no. 5; pp. 720 - 725
Main Authors Klaustermeyer, William B., Noritake, Dean T., Kwong, Frank K.
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.05.1987
Elsevier
Subjects
Adrenal Cortex Hormones - adverse effects
Adult
Aged
Aged, 80 and over
Asthma - drug therapy
Aurothioglucose - administration & dosage
Aurothioglucose - therapeutic use
Biological and medical sciences
Double-Blind Method
Gold - administration & dosage
Gold - therapeutic use
Humans
Infusions, Parenteral
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Respiratory system
Human
Corticosteroid
Drug combination
Chemotherapy
Respiratory disease
Gold Compounds
Intramuscular administration
Asthma
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Summary:The efficacy of parenteral gold therapy was evaluated in patients with steroid-dependent asthma. Five of eight patients improved in terms of reduced steroid requirement while they were maintaining or improving lung function. Two patients developed significant proteinuria that resolved with cessation of gold. Chrysotherapy appears to have a corticosteroid-sparing effect in some patients and may have a useful role in the management of severe refractory asthma.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-News-3
ISSN:0091-6749
1097-6825
DOI:10.1016/0091-6749(87)90202-8