Electrospinning of polysaccharides for regenerative medicine

Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerativ...

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Published inAdvanced drug delivery reviews Vol. 61; no. 12; pp. 1020 - 1032
Main Authors Lee, Kuen Yong, Jeong, Lim, Kang, Yun Ok, Lee, Seung Jin, Park, Won Ho
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 05.10.2009
Subjects
Electrochemistry
Electrospinning
Microscopy, Electron, Scanning
Molecular Structure
Nanofiber
Nanofibers - chemistry
Nanofibers - ultrastructure
Polysaccharide
Polysaccharides - chemistry
Polysaccharides - ultrastructure
Regenerative Medicine
Tissue Scaffolds - chemistry
Electrospinning
Nanofiber
Regenerative medicine
Polysaccharide
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Summary:Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.
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ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2009.07.006