The pyrogallol related compounds reduce UV-induced mutations in Escherichia coli B/r WP2

• Published in: Mutation research Vol. 173; no. 4; pp. 239 - 244
• Main Authors: Shimoi, Kayoko, Nakamura, Yoshiyuki, Tomita, Isao, Hara, Yukihiko, Kada, Tsuneo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.1986
• Subjects: Escherichia coli - genetics; Gallic Acid - pharmacology; Methylnitronitrosoguanidine - toxicity; Mutagenicity Tests; Mutation; Pyrogallol - analogs & derivatives; Pyrogallol - pharmacology; Ultraviolet Rays
• ISSN: 0165-7992; 0027-5107
• DOI: 10.1016/0165-7992(86)90017-5

Plant components with bio-antimutagenic activity were screened on UVC (254 nm)-induced mutagenesis using E. coli B/r WP2. The components with a pyrogallol moiety including gallic acid, (−)-epicatechin gallate (ECG), (−)-epigallocatechin (EGC) and (−)-epigallocatechin gallate (EGCG) reduced the mutation induction, but other components such as caffeic acid, chlorogenic acid and quercetin did not. The above compounds with a pyrogallol moiety were also effective on UVAB (295–400 nm)-induced mutagenesis, while they showed little effect on N-methyl- N′-nitrosoguanidine (MNNG)-induced mutagenesis. As this bio-antimutagenetic effect was not seen in the DNA excision-repair-deficient strains WP2 S and ZA159, the activity by the above plant components might be based on the promotion of the excision-repair system in E. coli B/r WP2.