The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices

• Published in: European journal of pharmacology Vol. 117; no. 3; p. 369
• Main Authors: Matsumura, Y, Sasaki, Y, Shinyama, H, Morimoto, S
• Format: Journal Article
• Language: English
• Published: Netherlands 19.11.1985
• Subjects: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium - physiology; In Vitro Techniques; Ion Channels - drug effects; Kidney Cortex - drug effects; Kidney Cortex - metabolism; Male; Nifedipine - analogs & derivatives; Nifedipine - pharmacology; Rats; Rats, Inbred Strains; Renin - metabolism
• DOI: 10.1016/0014-2999(85)90011-1
• ISSN: 0014-2999

The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. The inhibitory effect of Bay K 8644 on this release was abolished when calcium was excluded from the incubation medium. Nifedipine exerted a concentration-dependent blocking action on the inhibition of renin release by Bay K 8644. These findings support the proposal that calcium influx into the renin secretory cells is an inhibitory signal for renin release.