The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices

The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM po...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 117; no. 3; p. 369
Main Authors Matsumura, Y, Sasaki, Y, Shinyama, H, Morimoto, S
Format Journal Article
LanguageEnglish
Published Netherlands 19.11.1985
Subjects
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Animals
Calcium - physiology
In Vitro Techniques
Ion Channels - drug effects
Kidney Cortex - drug effects
Kidney Cortex - metabolism
Male
Nifedipine - analogs & derivatives
Nifedipine - pharmacology
Rats
Rats, Inbred Strains
Renin - metabolism
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Summary:The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. The inhibitory effect of Bay K 8644 on this release was abolished when calcium was excluded from the incubation medium. Nifedipine exerted a concentration-dependent blocking action on the inhibition of renin release by Bay K 8644. These findings support the proposal that calcium influx into the renin secretory cells is an inhibitory signal for renin release.
ISSN:0014-2999
DOI:10.1016/0014-2999(85)90011-1