Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria
The tocotrienol-rich-fraction (TRF) from palm oil, being tried as a more economical and efficient substitute for α-tocopherol, significantly inhibited oxidative damage in vitro to both lipids and proteins in rat brain mitochondria induced by ascorbate-Fe 2+, the free radical initiator azobis(2-amido...
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Published in | Neuroscience letters Vol. 195; no. 3; pp. 179 - 182 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
11.08.1995
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The tocotrienol-rich-fraction (TRF) from palm oil, being tried as a more economical and efficient substitute for α-tocopherol, significantly inhibited oxidative damage in vitro to both lipids and proteins in rat brain mitochondria induced by ascorbate-Fe
2+, the free radical initiator azobis(2-amidopropane)dihydrochloride (AAPH) and photosensitisation. The observed inhibitory effect was both time-and concentration-dependent. At a low concentration of 5μM, TRF can significantly inhibit oxidative damage to both lipids and proteins. The inhibitory effect of TRF seems to be mainly due to γ-tocotrienol and to a lesser extent α- and δ-tocotrienols. TRF was significantly more effective than α-tocopherol. This fraction from palm oil can be considered a natural antioxidant supplement capable of protecting the brain against oxidative damage and thereby from the ensuing adverse alterations. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/0304-3940(95)11812-B |