Comparison of the inhibitory roles of neuropeptide Y and galanin on cardiac vagal action in the dog

Prolonged attenuation of cardiac vagal action occurs following cardiac sympathetic nerve stimulation or intravenous neuropeptide Y (NPY) injections in anaesthetised dogs. Equimolar intravenous injections of galanin (GAL) had no effect on cardiac vagal action in this species. Immunohistochemical anal...

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Bibliographic Details
Published inNeuroscience letters Vol. 139; no. 2; p. 275
Main Authors Moriarty, M, Gibbins, I L, Potter, E K, McCloskey, D I
Format Journal Article
LanguageEnglish
Published Ireland 25.05.1992
Subjects
Anesthesia
Animals
Dogs
Electric Stimulation
Female
Galanin
Heart - drug effects
Heart - innervation
Immunohistochemistry
Male
Neuropeptide Y - pharmacology
Norepinephrine - pharmacology
Peptides - pharmacology
Stellate Ganglion - drug effects
Sympathetic Nervous System - drug effects
Tyrosine 3-Monooxygenase - metabolism
Vagus Nerve - drug effects
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Summary:Prolonged attenuation of cardiac vagal action occurs following cardiac sympathetic nerve stimulation or intravenous neuropeptide Y (NPY) injections in anaesthetised dogs. Equimolar intravenous injections of galanin (GAL) had no effect on cardiac vagal action in this species. Immunohistochemical analysis of dog stellate ganglia and cardiac muscle showed that most nerve cell bodies showing tyrosine hydroxylase immunoreactivity (TH-IR) also showed immunoreactivity to both NPY and GAL. The results are consistent with the proposal that NPY released from cardiac sympathetic nerves is responsible for the prolonged inhibition of cardiac vagal action known to be caused by such stimulation. A role for GAL, shown here to exist in cardiac sympathetic nerves in the dog, has yet to be determined.
ISSN:0304-3940
DOI:10.1016/0304-3940(92)90570-w