What does PD-L1 positive or negative mean?

Expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) is used to select patients and analyze responses to anti–PD-1/L1 antibodies. The expression of PD-L1 is regulated in different ways, which leads to a different significance of its presence or absence. PD-L1 positivity may be a result of ge...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 213; no. 13; pp. 2835 - 2840
Main Authors Ribas, Antoni, Hu-Lieskovan, Siwen
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 12.12.2016
Subjects
Animals
B7-H1 Antigen - genetics
B7-H1 Antigen - immunology
Humans
Neoplasm Proteins - genetics
Neoplasm Proteins - immunology
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - pathology
Programmed Cell Death 1 Receptor - genetics
Programmed Cell Death 1 Receptor - immunology
Reviews
T-Lymphocytes - immunology
T-Lymphocytes - pathology
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Summary:Expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) is used to select patients and analyze responses to anti–PD-1/L1 antibodies. The expression of PD-L1 is regulated in different ways, which leads to a different significance of its presence or absence. PD-L1 positivity may be a result of genetic events leading to constitutive PD-L1 expression on cancer cells or inducible PD-L1 expression on cancer cells and noncancer cells in response to a T cell infiltrate. A tumor may be PD-L1 negative because it has no T cell infiltrate, which may be reversed with an immune response. Finally, a tumor that is unable to express PD-L1 because of a genetic event will always be negative for PD-L1 on cancer cells.
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ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20161462