Antimutagenic effects of germanium oxide on Trp-P-2-induced frameshift mutations in Salmonella typhimurium TA98 and TA1538

A germanium compound, germanium oxide (GeO2) behaved as a potent antimutagen on frameshift-type reverse mutations induced by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in strains of Salmonella typhimurium TA98 and TA1538 with and without a plasmid pKM101, respectively. This metal antimutagen...

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Bibliographic Details
Published inMutation research Vol. 125; no. 2; p. 145
Main Authors Kada, T, Mochizuki, H, Miyao, K
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1984
Subjects
Animals
Biotransformation
Carbolines - toxicity
Germanium - pharmacology
Indoles - toxicity
Kinetics
Male
Microsomes, Liver - metabolism
Mutagenicity Tests
Mutagens - toxicity
Mutation
Rats
Rats, Inbred Strains
Salmonella typhimurium - drug effects
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Summary:A germanium compound, germanium oxide (GeO2) behaved as a potent antimutagen on frameshift-type reverse mutations induced by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in strains of Salmonella typhimurium TA98 and TA1538 with and without a plasmid pKM101, respectively. This metal antimutagen seems to work independently of the plasmid, a promotive factor in chemically induced mutagenesis through error-prone DNA repair.
ISSN:0027-5107
DOI:10.1016/0027-5107(84)90066-6