Genotoxic effects of deltamethrin in the mouse bone marrow micronucleus assay

The genotoxicity of deltamethrin was studied in Swiss albino male mice (five animals/group) using the bone marrow micronucleus assay. Deltamethrin (two i.p. injections, 30 h and 6 h before sample collection) was found to induce micronuclei at 162.5 and 300.0 mg/kg body weight. A lower dose (32.5 mg/...

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Published inMutation research Vol. 346; no. 4; pp. 203 - 206
Main Authors Gandhi, G., Chowdhury, J.B., Sareen, P.K., Dhillon, V.P.S.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.04.1995
Elsevier
Subjects
Animals
Biological and medical sciences
Bone Marrow - drug effects
Bone marrow cells
Chemical mutagenesis
Deltamethrin
Dose-Response Relationship, Drug
Insecticides - toxicity
Male
Medical sciences
Mice
Micronuclei
Micronucleus Tests
Nitriles
Pyrethrins - toxicity
Toxicology
Deltamethrin
Micronuclei
Bone marrow cells
Vertebrata
Mammalia
Insecticide
Micronucleus test
Mouse
Mutagenicity testing
Toxicity
Rodentia
Pesticides
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Summary:The genotoxicity of deltamethrin was studied in Swiss albino male mice (five animals/group) using the bone marrow micronucleus assay. Deltamethrin (two i.p. injections, 30 h and 6 h before sample collection) was found to induce micronuclei at 162.5 and 300.0 mg/kg body weight. A lower dose (32.5 mg/kg body weight) failed to induce a significant increase in micronuclei over the control level.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0165-7992
0027-5107
DOI:10.1016/0165-7992(95)90036-5