BCL-2 proteins and apoptosis: Recent insights and unknowns

• Published in: Biochemical and biophysical research communications Vol. 500; no. 1; pp. 26 - 34
• Main Author: Edlich, Frank
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.05.2018
• Subjects: 60 APPLIED LIFE SCIENCES; APOPTOSIS; B-lymphocytes; BCL-2 proteins; BH3-only proteins; caspases; cytosol; death; LYMPHOMAS; MITOCHONDRIA; Mitochondrial apoptosis; mitochondrial membrane; neoplasms; proteins; Retrotranslocation; therapeutics; THERAPY; Mitochondrial apoptosis; Retrotranslocation; BH3-only proteins; BCL-2 proteins

Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway. The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death by permeabilizing the outer mitochondrial membrane (OMM) and subsequent initiation of the caspase cascade. Therefore, the a...