Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors

• Published in: Archives of oral biology Vol. 73; pp. 223 - 229
• Main Authors: Nascimento, Marcelo Anderson Barbosa, DDS, MSc, PhD Student, Nonaka, Cassiano Francisco Weege, DDS, PhD, Barboza, Carlos Augusto Galvão, DDS, PhD, Freitas, Roseana de Almeida, DDS, PhD, Pereira Pinto, Leão, DDS, PhD, Souza, Lélia Batista de, DDS, PhD
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2017
• Subjects: Adenomatoid odontogenic tumor; Advanced Basic Science; Ameloblastoma; Ameloblastoma - immunology; Ameloblastoma - metabolism; Ameloblastoma - pathology; Biomarkers, Tumor - biosynthesis; Bone Morphogenetic Protein 2 - biosynthesis; Bone Morphogenetic Protein 2 - immunology; Bone Morphogenetic Protein 4 - biosynthesis; Bone Morphogenetic Protein 4 - immunology; Bone Morphogenetic Protein Receptors, Type I - biosynthesis; Bone Morphogenetic Protein Receptors, Type I - immunology; Bone Morphogenetic Protein Receptors, Type II - biosynthesis; Bone Morphogenetic Protein Receptors, Type II - immunology; Bone morphogenetic proteins; Cell Differentiation - physiology; Dentistry; Endothelial Cells - metabolism; Endothelial Cells - pathology; Fibroblasts - metabolism; Fibroblasts - pathology; Humans; Immunohistochemistry; Jaw Neoplasms - immunology; Jaw Neoplasms - metabolism; Jaw Neoplasms - pathology; Parenchymal Tissue - metabolism; Parenchymal Tissue - pathology; Stromal Cells - metabolism; Stromal Cells - pathology; Immunohistochemistry; Ameloblastoma; Adenomatoid odontogenic tumor; Bone morphogenetic proteins
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2016.10.022

Highlights • We analyzed the expression of BMPs-2 and -4 and their receptors (BMPR-IA and BMPR-II) in SAs, UAs, and AOTs. • BMP-2, BMP-4, BMPR-IA and BMPR-II were detected in all cases studied. • BMPs-2 and -4 and their receptors play an important role in the differentiation and development of ameloblastomas and AOTs. • These proteins may not explain the different biological behaviors of these lesions. • Alterations in the regulatory mechanisms of BMPs may contribute to their overexpression in ameloblastomas and AOTs.