Effects of Cadmium on the Activity of Matrix Metalloproteinases and Metallothionein Level in the Rat Brain

We studied the effects of long-lasting treating with cadmium in two different doses (0.1 and 1.0 μg/kg) on the activity of matrix metalloproteinases (MMP2 and MMP9) and metallothionein level in the rat brain. Cadmium in a higher dose (1 μg/kg) caused a decrease in MMP2 activity but increased that of...

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Published inNeurophysiology (New York) Vol. 49; no. 2; pp. 154 - 157
Main Authors Fomenko, O., Shiyntum, H., Shaulska, O., Shevtsova, A., Ushakova, G.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2017
Springer
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Brain
Cadmium
Cerebellum
Gelatinase A
Gelatinase B
Metallothionein
Nervous system diseases
Neurophysiology
Neurosciences
Rodents
Smoking
rat brain
metalloproteinases
cadmium
metallothionein
MMP9
MMP2
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Summary:We studied the effects of long-lasting treating with cadmium in two different doses (0.1 and 1.0 μg/kg) on the activity of matrix metalloproteinases (MMP2 and MMP9) and metallothionein level in the rat brain. Cadmium in a higher dose (1 μg/kg) caused a decrease in MMP2 activity but increased that of proMMP9 in the brain. The level of MT in the hippocampus and cerebellum dropped with both Cd doses. Thus, even small Cd doses exert specific effects on the MMP activity and MT level in the brain.
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-017-9645-7