Population-Based Human Papillomavirus Prevalence in Lampang and Songkla, Thailand

• Published in: The Journal of infectious diseases Vol. 187; no. 8; pp. 1246 - 1256
• Main Authors: Sukvirach, Sukhon, Smith, Jennifer S, Tunsakul, Sirirat, Muñoz, Nubia, Kesararat, Vitaya, Opasatian, Oranuj, Chichareon, Saibua, Kaenploy, Vichien, Ashley, Rhoda, Meijer, Chris J. L. M, Snijders, Peter J. F, Coursaget, Pierre, Franceschi, Silvia, Herrero, Rolando
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.04.2003; University of Chicago Press; Oxford University Press
• Subjects: Adolescent; Adult; Aged; Antibodies, Viral - blood; Biological and medical sciences; Cervical cancer; DNA, Viral - genetics; DNA, Viral - isolation & purification; Female; Human herpesvirus 2; Human respiratory syncytial virus; Human viral diseases; Humans; Infections; Infectious diseases; Life Sciences; Medical sciences; Middle Aged; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - immunology; Papillomavirus Infections - virology; Predisposing factors; Prevalence; Risk Factors; Sexual partners; Thailand - epidemiology; Tobacco smoking; Tropical medicine; Tumor Virus Infections - epidemiology; Tumor Virus Infections - immunology; Tumor Virus Infections - virology; Vaccination; Viral diseases; Viral diseases of the genital and urinary system; Viruses; Womens songs; Thailand; Asia; Human; Papillomavirus; Virus; Human papillomavirus; Prevalence; Papovaviridae; Woman; Epidemiology
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/373901

To investigate the prevalence and determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer, we studied 1741 women ⩾15 years of age from Lampang and Songkla, Thailand. Exfoliated cervical cells were collected for Papanicolaou smear screening and DNA detection of 36 different HPV types. Serum immunoglobulin G antibodies against L1 virus-like particles (anti-VLPs) of HPV-16, -18, -31, -33, and -58 were evaluated using enzyme-linked immunosorbent assay. Overall, 110 women (6.3%) were HPV DNA positive; the most common types were HPV-16, -52, and -72. The age-standardized prevalence of HPV DNA was higher among the 1035 women from Lampang (9.1%; 95% confidence interval [CI], 7.1–11.1) than among the 706 women from Songkla (3.9%; 95% CI, 2.3%–5.6%). Anti-VLPs were found in 21.8% of all women and were more frequent among women from Lampang (29.2%) than among women from Songkla (10.9%). Major risk factors for cervical HPV DNA were age <35 years, HSV-2 seropositivity, and having a husband with extramarital sexual partners