In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo me...

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Bibliographic Details
Published inOptics letters Vol. 39; no. 19; p. 5594
Main Authors Maher, Jason R, Jaedicke, Volker, Medina, Manuel, Levinson, Howard, Selim, Maria Angelica, Brown, William J, Wax, Adam
Format Journal Article
LanguageEnglish
Published United States 01.10.2014
Subjects
Animals
Burns - pathology
Disease Models, Animal
Mice
Skin - pathology
Tomography, Optical Coherence
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Summary:Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
ISSN:1539-4794
DOI:10.1364/ol.39.005594