In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography
Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo me...
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Published in | Optics letters Vol. 39; no. 19; p. 5594 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.10.2014
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Subjects | |
Online Access | Get more information |
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Summary: | Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology. |
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ISSN: | 1539-4794 |
DOI: | 10.1364/ol.39.005594 |