Usefulness of the d-ROMs test for prediction of cardiovascular events

• Published in: International journal of cardiology Vol. 222; pp. 226 - 232
• Main Authors: Masaki, Nobuyuki, Sato, Atsushi, Horii, Syumpei, Kimura, Toyokazu, Toya, Takumi, Yasuda, Risako, Namba, Takayuki, Yada, Hirotaka, Kawamura, Akio, Adachi, Takeshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2016
• Subjects: Aged; Cardiovascular; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - mortality; Cardiovascular Diseases - therapy; Cause of Death; d-ROMs; Disease Progression; Female; Humans; Japan - epidemiology; Male; Middle Aged; Myocardial Revascularization - statistics & numerical data; Oxidative stress; Oxidative Stress - physiology; Predictive Value of Tests; Prognosis; Reactive Oxygen Species - analysis; Risk Assessment - methods; Risk Factors; d-ROMs; oxidative stress; Oxidative stress
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2016.07.225

Abstract Background d-ROMs test developed to determine the degree of individual oxidative stress may predict cardiovascular events. Methods and Results 265 patients (204 men, 61 women; age, 65 ± 13 years) who had been treated for cardiovascular disease were divided evenly by quartile of baseline d-ROMs levels, and were followed up. During the observation periods of 2.66 ± 1.47 years, there were 14 (5%) deaths, 8 (3%) cardiovascular deaths, 13 (5%) major adverse cardiovascular events (MACEs), and 51 (19%) all cardiovascular events including heart failure, cardiovascular surgery, and revascularization. Log-rank tests demonstrated that the patients in the 4th quartile (d-ROMs ≧ 395.00 U.CARR) had a higher incidence rate of cardiovascular death than those in the 2nd quartile (d-ROMs 286.00–335.00, p = 0.022). In multivariate Cox regression analysis, even after adjustment for age, sex, coronary risk factors, C-reactive protein, and renal function, high d-ROMs was a risk factor for all-cause death [adjusted HR of 4th vs. 1st quartile, 10.791 (95% confidence interval 1.032–112.805), p = 0.047], and all cardiovascular events [HR of 4th vs. 1st quartile, 2.651 (95% confidence interval 1.138–6.177), p = 0.024]. Conclusions Our results suggest that d-ROMs is a useful oxidative stress marker to assess prognosis and risk of further cardiovascular events.