Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth With Perinatal Human Immunodeficiency Virus in the DC Cohort

Abstract We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0–19 years) in the United States and report an increased rate of change of BMI-for-age z score after initiating integrase strand transfer inhibitors (+0.19 z score units/year [95% confiden...

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Published inOpen forum infectious diseases Vol. 8; no. 7; p. ofab308
Main Authors Koay, Wei Li A, Dirajlal-Fargo, Sahera, Levy, Matthew E, Kulie, Paige, Monroe, Anne, Castel, Amanda D, Rakhmanina, Natella Y
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.07.2021
Subjects
Brief Reports
Editor's Choice
integrase inhibitors
HIV
adolescents
body mass index
youth
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Summary:Abstract We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0–19 years) in the United States and report an increased rate of change of BMI-for-age z score after initiating integrase strand transfer inhibitors (+0.19 z score units/year [95% confidence interval, .01–.37]; P = .036) for a median follow-up of 527.5 days. Children and youth with HIV in the United States (n=38) have an increased rate of change of BMI-for-age z-score (+0.19 z-score units/year) after initiating integrase strand transfer inhibitors for a median follow-up of 527.5 days.
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ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab308