Long Intergenic Noncoding RNAs: New Links in Cancer Progression

The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification...

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Published inCancer research (Chicago, Ill.) Vol. 71; no. 1; pp. 3 - 7
Main Authors Tsai, Miao-Chih, Spitale, Robert C., Chang, Howard Y.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.01.2011
Subjects
Antineoplastic agents
Biological and medical sciences
Disease Progression
Humans
Medical sciences
Mutation
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - therapy
Pharmacology. Drug treatments
RNA, Untranslated - genetics
Tumors
RNA
Tumor progression
Non coding sequence
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Summary:The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets. Cancer Res; 71(1); 3–7. ©2011 AACR.
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ISSN:0008-5472
1538-7445
1538-7445
DOI:10.1158/0008-5472.CAN-10-2483