Seven Alkaloids from Picrasma quassioides and Their Cytotoxic Activities

• Published in: Chemistry of natural compounds Vol. 50; no. 5; pp. 884 - 888
• Main Authors: Lai, Zheng-Quan, Liu, Wei-Hai, Ip, Siu-Po, Liao, Hui-Jun, Yi, Yu-Yang, Qin, Zhen, Lai, Xiao-Ping, Su, Zi-Ren, Lin, Zhi-Xiu
• Format: Journal Article
• Language: English
• Published: Boston Springer-Verlag 01.11.2014; Springer US; Springer Nature; Springer
• Subjects: Alkaloids; Chemistry; Chemistry, Medicinal; Chemistry, Organic; cytotoxicity; Life Sciences & Biomedicine; Medicine; Organic Chemistry; Pharmacology & Pharmacy; Pharmacy; Phenylalanine; Physical Sciences; Picrasma quassioides; Plant Sciences; Saponins; Science & Technology; spectroscopy; carboline alkaloids; canthin-6-one alkaloids; cytotoxic activities; BENNET; STEMS; Picrasma quassioides; beta-carboline alkaloids; CONSTITUENTS
• ISSN: 0009-3130; 1573-8388
• DOI: 10.1007/s10600-014-1106-6

A new alkaloid, 6-hydroxy-β-carboline-1-carboxylic acid (1), together with six known alkaloids, including β-carboline-1-carboxylic acid (2), β-carboline-1-propanoic acid (3), 1-methoxycarbonyl-β-carboline (4), 3-methylcanthin-5,6-dione (5), 5-hydroxy-4-methoxycanthin-6-one (6), and 4,5-dimethoxycanthin-6-one (7), were isolated from the stem of Picrasma quassioides. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–7 were screened for their cytotoxic activities against five cancer cell lines such as CT26.WT, K-562, SGC-7901, Hep G2, and A-549. Among the seven alkaloids tested, only compound 2 exhibited moderate inhibitory activities against K-562 and SGC-7901 cell lines.