Traffic-related air pollution is associated with airway hyperresponsiveness

• Published in: Journal of allergy and clinical immunology Vol. 133; no. 6; pp. 1763 - 1765.e2
• Main Authors: Kim, Byoung-Ju, MD, PhD, Lee, So-Yeon, MD, PhD, Kwon, Ji-Won, MD, Jung, Young-Ho, MD, Lee, Eun, MD, Yang, Song I., MD, Kim, Hyung-Young, MD, Seo, Ju-Hee, MD, Kim, Hyo-Bin, MD, PhD, Kim, Hwan-Cheol, MD, PhD, Leem, Jong-Han, MD, PhD, Kwon, Ho-Jang, MD, PhD, Hong, Soo-Jong, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2014; Elsevier Limited
• Subjects: Age; Air Pollution; Allergies; Allergy and Immunology; Asthma; Body mass index; Humans; Nitrogen dioxide; Respiratory Hypersensitivity - epidemiology; Respiratory Hypersensitivity - etiology; Roads & highways; Studies; Tobacco smoke; Vehicle Emissions
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2014.01.020

[...]we examined the effects of air pollution on AHR in a nationwide prospective epidemiologic study.4,7 The study population was derived from a prospective 2-year follow-up survey consisting of parental responses to the International Studies of Asthma Allergic diseases in Childhood (ISAAC) questionnaire and allergic evaluation, including methacholine challenge test, skin prick test, and pulmonary function test. [...]their study population was a cohort of adults aged 18 to 70 years, and only cross-sectional association was analyzed. [...]it may be postulated that there is a critical period of development during which a person is vulnerable to air pollution.