Persistence of long-lasting serotonin depletion by p-chloroamphetamine in rat brain after 6-hydroxydopamine lesioning of dopamine neurons

• Published in: Biochemical pharmacology Vol. 50; no. 8; pp. 1305 - 1307
• Main Authors: Perry, Kenneth W., Kostrzewa, Richard M., W. Fuller, Ray
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 12.10.1995; Elsevier Science
• Subjects: 6-hydroxydopamine; Animals; Animals, Newborn; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Corpus Striatum - drug effects; Corpus Striatum - metabolism; dopamine; Dopamine - deficiency; Drug addictions; hippocampus; Medical sciences; Oxidopamine; p-chloroamphetamine; p-Chloroamphetamine - pharmacology; Rats; Rats, Sprague-Dawley; serotonin; Serotonin - deficiency; Serotonin Agents - pharmacology; striatum; Toxicology; 6OHDA, 6-hydroxydopamine; serotonin; 6-hydroxydopamine; striatum; hippocampus; pCA, p-chloroamphetamine; 5HIAA, 5-hydroxyindoleacetic acid; DOPAC, 3,4-dihydroxyphenylacetic acid; MDMA, 3,4-methylenedioxymethamphetamine; and HVA, homovanillic acid; p-chloroamphetamine; dopamine; Amphetamine derivatives; Dopamine; Rat; Serotonin; Toxicity; Rodentia; Central nervous system; Corpus striatum; Catecholamine; Vertebrata; Mammalia; Depletion; Neuromediator; Central nervous system disease; Drug of abuse; Long lasting; Brain (vertebrata)
• ISSN: 0006-2952; 1873-2968
• DOI: 10.1016/0006-2952(95)00248-X

In rats that had been treated neonatally with 6-hydroxydopamine (6OHDA) to deplete striatal dopamine more than 95%, a single injection of p-chloroamphetamine (pCA) (5 or 10 mg/kg, i.p.) resulted in depletion of striatal and hippocampal serotonin at 1 week to a similar extent as in control rats. These findings suggest that striatal dopamine is not essential to the long-lasting depletion of brain serotonin by pCA in rats.